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A blister is a bag of fluid under the skin. The clear, watery fluid inside the blister is called serum. This serum comes from the surrounding tissues in response to broken skin. If the blister is closed, the serum provides natural protection to the skin under the blister. The small blisters called vesicles. Those longer than half an inch (1.27 cm) are called blisters. A blood blister is filled with blood instead of serum.

There are many reasons for forming a blister, these include:

* Irritation: blisters can be formed by physical factors that irritate the skin, such as friction (rubbing the skin), irritating chemicals, extreme cold or heat. Blisters on the feet can be caused by shoes that are too tight or scraping the skin in a particular area. The blisters may also be caused by contact dermatitis, a skin reaction to some type of chemical irritant. The intense cold can trigger frostbite, which often lead to blisters once the skin returns to normal temperature is reached. Any type of burn, even the sun can also form blisters.
* Allergies: allergic contact dermatitis, a form of dermatitis or eczema, can cause blisters. Allergic contact dermatitis is caused by an allergy to a chemical or toxin, poison ivy, poison oak or poison sumac.
* Infections: Infections that cause blisters include bullous impetigo, a skin infection caused by staph, viral infections, sores and genital areas caused by the herpes simplex virus (type 1 and 2), varicella zoster (shingles) , which are caused by the varicella-zoster virus, and Coxsackie virus infections. which are very common during childhood.
* Skin: Many skin conditions cause blisters. Examples include edermatitis herpetiformis, pemphigoid and pemphigus. There are also inherited forms of conditions of blisters on the skin, such as epidermolysis bullosa (where the pressure commonly causes blisters) and porphyria cutanea tarda (where exposure to the sun causes blisters).
* Medications: Many medications, such as nalidixic acid (NegGram) and furosemide (Lasix) can cause skin reactions in ampullary. Others, such as doxycycline (Vibramycin), may increase the risk of blistering sunburn by increasing skin sensitivity to sunlight exposure. In more drastic cases, the drugs can trigger more severe ampullary diseases may endanger life, such as erythema Polymorphic or toxic epidermal necrolysis, also known as NET, a disease that causes acute damage to the skin and usually affects the 30% or more of the body surface.

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