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In most cases, the cause of RLS is unknown (which is called idiopathic). There is a family history of disease in approximately 50 percent of cases, suggesting a genetic form of the disorder. People with the inherited form of RLS tend to be younger when symptoms start and have a slower progression of the disease.

In other cases, RLS appears to be related to the following factors or conditions, although researchers do not yet know whether these factors actually cause the syndrome.

People with low iron levels or anemia may be prone to developing RLS. Once you have corrected the iron levels or anemia, patients may see a decrease in symptoms.
Chronic diseases such as kidney failure, diabetes, Parkinson’s disease, and peripheral neuropathy associated with RLS. When the primary disease is often obtained relief from the symptoms of RLS.
Some pregnant women experience RLS, especially in its last quarter. In most of these women, symptoms usually disappear within 4 weeks of delivery.

Some medications, such as drugs to prevent nausea (prochlorperazine or metoclopramide), seizures (phenytoin or droperidol), the antipsychotic (haloperidol or phenothiazine derivatives), and some medicines for colds or allergies, can aggravate the symptoms. Patients can consult with your doctor about changing medications.

Researchers have also found that caffeine, alcohol, snuff and can aggravate or cause symptoms in patients predisposed to develop RLS. Some studies have shown that a reduction or total elimination of such substances may relieve symptoms, although it is unclear whether the elimination of these substances can prevent RLS symptoms from occurring at all.

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