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AIDS is the most feared disease at this time. HIV, the virus that causes this disease, damages the body’s defense system (immune system), so that people who suffer from this disease’s ability to defend itself from disease attack is reduced. . As a result, viruses, fungi and bacteria are usually harmless to extremely dangerous because the body’s immune system damage.

Because this disease ferociously, then the various efforts made to develop drugs that can be overcome. Developing treatments that currently, the target is the enzymes produced by HIV and needed by the virus to grow, These enzymes is inhibited by using inhibitors which would inhibit enzymes work and will ultimately inhibit the growth of the HIV virus.

HIV is a virus which genetic material is RNA (ribonucleic acid) which is covered by a matrix which is composed largely of proteins. To grow, this genetic material needed to be changed into DNA (deoxyribonucleic acid), integrated into the host DNA, and then undergo a process that eventually will produce proteins. Will produced and will form new viruses.

Drugs that have been found at this time inhibit the conversion of RNA into DNA and inhibit the formation of active proteins. Enzymes that help the conversion of RNA into DNA is called reverse transcriptase, while helping the formation of active proteins called proteases.

To be able to form an active protein, the genetic information stored in RNA viruses must be first converted into DNA. Reverse transcript assist the process of conversion of RNA into DNA. If the process of DNA formation is inhibited, then the process of protein also becoming restricted. Therefore, the formation of viruses that have only been running low. Thus, the use of drugs inhibiting the reverse transcriptase enzyme was not completely destroyed the virus contained in the body. The use of drugs of this type only inhibits the formation of new viruses, and this inhibition process can not stop the formation of a new virus.

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